Short-term teriparatide delivery and osseointegration: a clinical feasibility study.
Identifieur interne : 003F99 ( Main/Exploration ); précédent : 003F98; suivant : 004000Short-term teriparatide delivery and osseointegration: a clinical feasibility study.
Auteurs : U. Kuchler [Autriche] ; E R Luvizuto ; S. Tangl ; G. Watzek ; R. GruberSource :
- Journal of dental research [ 1544-0591 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Agents de maintien de la densité osseuse (pharmacologie), Femelle, Humains, Implants dentaires, Mandibule, Mâchoire édentée, Mâle, Ostéo-intégration (), Pose d'implant dentaire endo-osseux, Sujet âgé, Sujet âgé de 80 ans ou plus, Titane, Tériparatide (pharmacologie), Études de faisabilité, Études longitudinales.
- MESH :
- pharmacologie : Agents de maintien de la densité osseuse, Tériparatide.
- Adulte d'âge moyen, Femelle, Humains, Implants dentaires, Mandibule, Mâchoire édentée, Mâle, Ostéo-intégration, Pose d'implant dentaire endo-osseux, Sujet âgé, Sujet âgé de 80 ans ou plus, Titane, Études de faisabilité, Études longitudinales.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Bone Density Conservation Agents (pharmacology), Dental Implantation, Endosseous, Dental Implants, Feasibility Studies, Female, Humans, Jaw, Edentulous, Longitudinal Studies, Male, Mandible, Middle Aged, Osseointegration (drug effects), Teriparatide (pharmacology), Titanium.
- MESH :
- chemical , pharmacology : Bone Density Conservation Agents, Teriparatide.
- drug effects : Osseointegration.
- Aged, Aged, 80 and over, Dental Implantation, Endosseous, Dental Implants, Feasibility Studies, Female, Humans, Jaw, Edentulous, Longitudinal Studies, Male, Mandible, Middle Aged, Titanium.
Abstract
Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on the osseointegration of titanium implants have not been performed. We conducted an open-label randomized controlled feasibility study and included 24 individuals with edentulous lower jaws. The participants received 2 study implants in the mandible during interforaminal dental implant surgery. They were randomly assigned to receive either 20 µg of teriparatide once daily for 28 days or no treatment. Study implants were retrieved from 23 participants after 9 weeks and were subjected to histomorphometric analyses. Endpoints were new bone-volume-per-tissue-volume (NBV/TV) and new bone-to-implant-contact (NBIC). We report here that median values of NBV/TV in the control and the teriparatide groups were 15.4% vs. 17.6% in the periosteal compartment, 11.3% vs. 16.5% in the cortical compartment, and 7.3% vs. 12.0% in the medullary compartment, respectively. NBIC median values in the control and the teriparatide groups were 3.3% vs. 4.1% in the periosteal compartment, 5.0% vs. 4.4% in the cortical compartment, and 0.3% vs. 1.4% in the medullary compartment, respectively. The results provide the first histological data on the osseointegration of titanium study implants in individuals treated with teriparatide. ClinicalTrials.gov number, NCT00089674.
DOI: 10.1177/0022034511407920
PubMed: 21555773
Affiliations:
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Tangl</name></author><author><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G" last="Watzek">G. Watzek</name></author><author><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R" last="Gruber">R. 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Kuchler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Surgery, Medical University of Vienna, Sensengasse 2a, A-1090 Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Oral Surgery, Medical University of Vienna, Sensengasse 2a, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Luvizuto, E R" sort="Luvizuto, E R" uniqKey="Luvizuto E" first="E R" last="Luvizuto">E R Luvizuto</name></author><author><name sortKey="Tangl, S" sort="Tangl, S" uniqKey="Tangl S" first="S" last="Tangl">S. Tangl</name></author><author><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G" last="Watzek">G. Watzek</name></author><author><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R" last="Gruber">R. Gruber</name></author></analytic><series><title level="j">Journal of dental research</title><idno type="eISSN">1544-0591</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Bone Density Conservation Agents (pharmacology)</term><term>Dental Implantation, Endosseous</term><term>Dental Implants</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Jaw, Edentulous</term><term>Longitudinal Studies</term><term>Male</term><term>Mandible</term><term>Middle Aged</term><term>Osseointegration (drug effects)</term><term>Teriparatide (pharmacology)</term><term>Titanium</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Agents de maintien de la densité osseuse (pharmacologie)</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Mandibule</term><term>Mâchoire édentée</term><term>Mâle</term><term>Ostéo-intégration ()</term><term>Pose d'implant dentaire endo-osseux</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Titane</term><term>Tériparatide (pharmacologie)</term><term>Études de faisabilité</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Bone Density Conservation Agents</term><term>Teriparatide</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Osseointegration</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term><term>Tériparatide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Dental Implantation, Endosseous</term><term>Dental Implants</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Jaw, Edentulous</term><term>Longitudinal Studies</term><term>Male</term><term>Mandible</term><term>Middle Aged</term><term>Titanium</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Implants dentaires</term><term>Mandibule</term><term>Mâchoire édentée</term><term>Mâle</term><term>Ostéo-intégration</term><term>Pose d'implant dentaire endo-osseux</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Titane</term><term>Études de faisabilité</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on the osseointegration of titanium implants have not been performed. We conducted an open-label randomized controlled feasibility study and included 24 individuals with edentulous lower jaws. The participants received 2 study implants in the mandible during interforaminal dental implant surgery. They were randomly assigned to receive either 20 µg of teriparatide once daily for 28 days or no treatment. Study implants were retrieved from 23 participants after 9 weeks and were subjected to histomorphometric analyses. Endpoints were new bone-volume-per-tissue-volume (NBV/TV) and new bone-to-implant-contact (NBIC). We report here that median values of NBV/TV in the control and the teriparatide groups were 15.4% vs. 17.6% in the periosteal compartment, 11.3% vs. 16.5% in the cortical compartment, and 7.3% vs. 12.0% in the medullary compartment, respectively. NBIC median values in the control and the teriparatide groups were 3.3% vs. 4.1% in the periosteal compartment, 5.0% vs. 4.4% in the cortical compartment, and 0.3% vs. 1.4% in the medullary compartment, respectively. The results provide the first histological data on the osseointegration of titanium study implants in individuals treated with teriparatide. ClinicalTrials.gov number, NCT00089674.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><noCountry><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R" last="Gruber">R. Gruber</name><name sortKey="Luvizuto, E R" sort="Luvizuto, E R" uniqKey="Luvizuto E" first="E R" last="Luvizuto">E R Luvizuto</name><name sortKey="Tangl, S" sort="Tangl, S" uniqKey="Tangl S" first="S" last="Tangl">S. Tangl</name><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G" last="Watzek">G. Watzek</name></noCountry><country name="Autriche"><noRegion><name sortKey="Kuchler, U" sort="Kuchler, U" uniqKey="Kuchler U" first="U" last="Kuchler">U. Kuchler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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